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KMID : 0191120220370290238
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Journal of Korean Medical Science
2022 Volume.37 No. 29 p.238 ~ p.238
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Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy
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Park Do-Hyeon
Lee Chan-Mi
Chang Eui-Jin
Kang Chang-Kyung
Park Wan-Beom
Kim Nam-Joong
Choe Pyoeng-Gyun
Oh Myoung-Don
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Abstract
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Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has not been evaluated. We conducted retrospective propensity score-matched case-control study of 233 COVID-19 patients with moderate to severe illnesses who required oxygen therapy and evaluated whether empirical antibiotic therapy could improve clinical outcomes. Empirical antibiotic therapy did not improve clinical outcomes including length of stay, days with oxygen requirement, the proportion of patients with increased oxygen demand, the proportion of patients who required mechanical ventilation, and overall mortality. This finding implies that routine administration of antibiotics for the treatment of COVID-19 is not essential and should be restricted.
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KEYWORD
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Coronavirus Disease 2019, Antibiotics, Antimicrobial Stewardship
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